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About JNT-517 JNT-517 is a selective small molecule inhibitor of the phenylalanine transporter SLC6A19 that has the potential to be a first-in-class oral therapy used to treat any person with PKU.
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Jalan Raya Cinunuk, Cinunuk, Kabupaten Bandung, Jawa Barat, Indonesia. Cabang J&T Express Peta, Nomor telepon, Pelayanan J&T Express CP CINUNUK, Kabupaten Bandung, Jawa Barat.
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JNT-517 was derived from an allosteric inhibitor series identified by RAPID. A proprietary cryo-EM structure of SLC6A19 in complex with a Jnana proprietary compound has revealed that Jnana's allosteric inhibitors bind in an unprecedented cryptic allosteric site on the SLC transporter. Immune-Mediated Diseases. Undisclosed.
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JNT-517 is a selective small molecule inhibitor of the phenylalanine transporter SLC6A19 that has the potential to be a first-in-class oral therapy used to treat any person with PKU, regardless of age or genotype. JNT-517 acts at a novel, cryptic allosteric site to block kidney reabsorption of Phe and offers a promising new approach to reduce.
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JNT-517 is a Potential First-in-Class Oral Treatment for PKU; Phase 1b Study Follows Positive Clinical Proof of Mechanism Data in Healthy Individuals Upcoming Oral Presentation of Phase 1a Study Results at the Society for the Study of Inborn Errors of Metabolism (SSIEM) Annual Symposium 2023 BOSTON, August 9, 2023 - Jnana Therapeutics,a clinical-stage biotechnology company…
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All participants in Part C will receive JNT-517. The goal of Part D is to assess the safety, tolerability, PK, and effect on urinary Phe and other amino acids of JNT-517 in participants with phenylketonuria (PKU). Participants in Part D will receive either JNT-517 or placebo and will be blinded to their treatment assignment.
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About JNT-517 JNT-517 is a selective small molecule inhibitor of the phenylalanine transporter SLC6A19 that has the potential to be a first-in-class oral therapy used to treat any person with PKU.
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Series C financing led by Bain Capital Life Sciences to support PKU program and pipeline in immune-mediated diseases and cancer; Ron Renaud joins Jnana's Board of Directors Jnana initiates Phase 1 clinical trial of JNT-517, a potential first-in-class oral treatment for PKU; JNT-517 receives US FDA Rare Pediatric Disease Designation BOSTON, Mass., November 15, 2022…
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