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Clopidogrel is used to prevent heart attacks and strokes in persons with heart disease (recent heart attack), recent stroke, or blood circulation disease (peripheral vascular disease).. Clopidogrel is also used with aspirin to treat new/worsening chest pain (new heart attack, unstable angina) and to keep blood vessels open and prevent blood clots after certain procedures (such as cardiac stent).
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Side Effects. Easy bleeding/bruising, stomach upset/pain, diarrhea, and constipation may occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Remember that.
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Clopidogrel oral tablet is a prescription drug that's available as the brand-name drug Plavix.It's also available as a generic drug. Generic drugs usually cost less than the brand-name version.
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2. Clopidogrel pharmacokinetics and pharmacodynamics. Following oral administration, about 50% of the dose is absorbed from the intestine based on urinary metabolites data [].Results from in vitro studies show that the uptake of clopidogrel into Caco-2 cells is limited by P-glycoprotein (P-gp, ABCB1), which suggests that P-gp may affect the intestinal absorption and oral bioavailability of.
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Oral: 75 mg once daily in combination with aspirin; duration of clopidogrel depends on degree of stenosis. Stenosis of 50% to 69%: Clopidogrel may be added to aspirin for 21 days; after 21 days, discontinue clopidogrel and continue aspirin indefinitely (Ehtisham 2019).
clopidogrel 75 mg, 300 mg, tablet Mode of action Uses, Side Effects, Dosage, Pharmacology
Clopidogrel is an inactive prodrug that requires enzymatic activation via a variety of CYP enzymes, including the CYP2C19 and CYP3A4 enzymes, through a two-step process of bioactivation. Genetic polymorphisms to these enzymes can influence response to therapy.
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Methods. The study included patients receiving either a single 300 mg loading dose of clopidogrel (n = 17) or a 75 mg dose (n = 45) for at least 7 days before sample collection.The concentrations of clopidogrel and its metabolites—the inactive H3 and the pharmacologically active H4 isomers of the thiol metabolite and the inactive carboxylic acid metabolite—in plasma samples (stabilized.
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Clopidogrel merupakan pengencer darah, yang bekerja dengan menghambat pelekatan trombosit dan penyumbatan berbahaya. Clopidogrel digunakan untuk mengurangi kejadian trombolitik pada infark miokard yang belum lama terjadi, stroke, atau penyakit arteri perifer, sindrom koroner akut.
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Keterbukaan Informasi. CLOPIDOGREL. CLOPIDOGREL. Womens Running Shoes & Running Clothes. Jakarta Pusat - 10110. 1-500-255. 24 hours. Kimia Farma adalah perusahaan industri farmasi pertama dan terbesar di Indonesia yang didirikan sejak tahun 1817.
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The typical dosage of clopidogrel is 75 milligrams (mg) taken once daily. For people with acute coronary syndrome, doctors typically recommend a one-time loading dose of 300 mg on the first day of.
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Clopidogrel comes as a tablet to take by mouth. It is usually taken once a day with or without food. Take clopidogrel at around the same time every day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take clopidogrel exactly as directed.
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Clopidogrel termasuk kategori obat yang memiliki sifat polimorfisme. Dua bentuk polimorfik Clopidogrel telah diidentifikasi dan ditetapkan sebagai Form 1 dan Form 2. Form 1 dan Form 2 memiliki indikasi yang sama. Perbedaan antara dua bentuk kristal terletak pada susunan kation Clopidogrel dan anion sulfat.
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Clopidogrel slows the blood's clotting action by making platelets less sticky. Platelets are blood cells that stick together to block cuts and breaks in blood vessels. But if you're at risk of heart attack or stroke, platelets can stick together inside already narrowed blood vessels to form a clot. The clot can stop blood flowing to the heart.
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Kimia Farma Sungwun Pharmacopia Cikarang, Indonesia Clopidogrel Bi-sulphate Form II API Products Clopidogrel Bi-sulphate Form II Classification: Anti-Platelet CAS: 120202-66-6 Pack Type: HDPE Drum 20 kg Certified: GMP and Halal MUI MoQ (Minimum of Quantity) Purchase: 1 kg For more info regarding specifications, please inquire us here
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Absorption. A 75mg oral dose of clopidogrel is 50% absorbed from the intestine. 9 Clopidogrel can be taken with or without food. 9 A meal decreases the AUC of the active metabolite by 57%. 9 The active metabolite of clopidogrel reaches a maximum concentration after 30-60 minutes. 9 Clopidogrel reached a C max of 2.04±2.0ng/mL in 1.40±1.07h. 5 The AUC for a 300mg oral dose of clopidogrel was.
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Clopidogrel (Plavix) Clopidogrel (Plavix®) is an antiplatelet drug you can take to prevent blood clots. It keeps platelets in your blood from coming together and making clots. You may need clopidogrel to prevent future issues if you had a heart attack, stroke or certain types of heart surgery. Additional Common Questions.